Garnock Valley rivals Kiilbirnie Ladeside, who became the first team to beat them in the league on Saturday, host top East Coast side Penicuik Athletic.
Dalry Thistle have a money-spinning home all-Ayrshire tie against holders Glenafton Athletic and Ardrossan Winton Rovers will be favoured to come through at home to borderers Dunbar.
Kilwinning Rangers host Central League Larkhall.
The draw as it affects Ayrshire sides is, as follows:
Shotts Bon Accord v Muirkirk
Auchinleck Talbot v Forres Thistle
Kilbirnie Ladeside v Penicuik Athletic
Forth Wanderers v Irvine Victoria
Irvine Meadow v Broxburn Athletic
Troon v Stoneyburn
Craigmark Burntonians v Cumnock
Kilwinning Rangers v Larkhall Thistle
Girvan v East Kilbride Thistle
Whitletts Victoria v Jeanfield Swifts
Ardrossan Winton Rovers v Dunbar United
Dalry Thistle v Glenafton Athletic
Beith v Inverness City
Sauchie v Largs Thistle
Hurlford United v Nairn St Ninian
Musselbrugh Athletic v Darvel
Lugar Boswell Thistle v Linlithgow Rose
Annbank United v Colony Park
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