Garnock Valley rivals Kiilbirnie Ladeside, who became the first team to beat them in the league on Saturday, host top East Coast side Penicuik Athletic.
Dalry Thistle have a money-spinning home all-Ayrshire tie against holders Glenafton Athletic and Ardrossan Winton Rovers will be favoured to come through at home to borderers Dunbar.

Kilwinning Rangers host Central League Larkhall.

The draw as it affects Ayrshire sides is, as follows:

Shotts Bon Accord v Muirkirk

Auchinleck Talbot v Forres Thistle

Kilbirnie Ladeside v Penicuik Athletic

Forth Wanderers v Irvine Victoria

Irvine Meadow v Broxburn Athletic

Troon v Stoneyburn

Craigmark Burntonians v Cumnock

Kilwinning Rangers v Larkhall Thistle

Girvan v East Kilbride Thistle

Whitletts Victoria v Jeanfield Swifts

Ardrossan Winton Rovers v Dunbar United

Dalry Thistle v Glenafton Athletic

Beith v Inverness City

Sauchie v Largs Thistle

Hurlford United v Nairn St Ninian

Musselbrugh Athletic v Darvel

Lugar Boswell Thistle v Linlithgow Rose

Annbank United v Colony Park